Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II

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Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II.

Chromatin spread techniques have been widely used to assess the dynamic localization of various proteins during gametogenesis, particularly for spermatogenesis. These techniques allow for visualization of protein and DNA localization patterns during meiotic events such as homologous chromosome pairing, synapsis and DNA repair. While a few protocols have been described in the literature, general...

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The role of chromatin modifications in progression through mouse meiotic prophase.

Meiosis is a key event in gametogenesis that generates new combinations of genetic information and is required to reduce the chromosome content of the gametes. Meiotic chromosomes undergo a number of specialised events during prophase to allow meiotic recombination, homologous chromosome synapsis and reductional chromosome segregation to occur. In mammalian cells, DNA physically associates with...

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ژورنال

عنوان ژورنال: Journal of Visualized Experiments

سال: 2018

ISSN: 1940-087X

DOI: 10.3791/56736